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Apcalis/Cialis 5mg - Where to buy in Thailand and cost ?


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Posted
3 hours ago, _Zoidberg_ said:

Gnenerally speaking, in capsule fabrication the the components mixing is made usually just before forming.

As a consequence there is no certainty that the active principle is uniformly distributed in the capsule.

So if you cut in two halves of 10mg, you cannot be sure that each contains 50% of initial quantity of Tadalafil.

Interesting! Do you have input on the method of putting a tab in a bottle of water and drink daily for, lets say, one week. Can the stuff go bad, or weak?

It would be convenient for me, instead of splitting a tab in 4 (or 8, if one want to do 2.5mg per day). 

Posted

Make life easy -buy a pill cuter !

Posted (edited)
20 hours ago, Jackie2013 said:

Interesting! Do you have input on the method of putting a tab in a bottle of water and drink daily for, lets say, one week. Can the stuff go bad, or weak?

It would be convenient for me, instead of splitting a tab in 4 (or 8, if one want to do 2.5mg per day). 

Some of PA posters do it and are satisfied.

I have tested this way with APcalis and found no significant problems conserving the water mixing up to a week.
 

Just let me report some more stable literature: (I know: some fellow will find this a too long post ;-)

https://www.ema.europa.eu/en/documents/scientific-discussion/cialis-epar-scientific-discussion_en.pdf

https://www.tandfonline.com/doi/full/10.1080/00319104.2022.2048385

https://pubmed.ncbi.nlm.nih.gov/33249149/

https://link.springer.com/article/10.1007/s40005-015-0196-x

https://www.sciencedirect.com/science/article/abs/pii/S1773224717303817


"Tadalafil is practically insoluble in water. It does not possess any ionisable groups in the pH range of
1-11 and, subsequently, does not demonstrate any changes in solubility in aqueous buffers in that
range. It is freely soluble only in solvents such as dimethylsulfoxide and dimethylformamide."

"Stability Studies on the solid state, solutions and suspensions of the active substance at different
conditions were carried out. No degradation or physical changes were observed in tadalafil at its solid
state under heat, humidity and light exposure. However, degradation was observed in solutions and
suspensions of the active substance at different pH values, light and oxidative conditions."

"The formulation contains stable, milled tadalafil drug substance and incorporated into a wet
granulation to consistently produce tablets with good homogeneity and the desired dissolution
characteristics. To achieve a dosage form with a rapid therapeutic onset, the excipients included in the
formulation were selected and adjusted to promote rapid absorption. This combination of ingredients
has produced a material (free-flowing, easily wetted and compressible) as well as tablets that possess
the desired physical characteristics of low friability, acceptable hardness and rapid disintegration.
After that, film coating stage produce film-coated tablets with a uniform appearance, easy to swallow
with little or no impact on the dissolution profile"

 

So, why EMA (and other cited researchers) say that Tadalafil is almost insoluble in water but we all have a very different experience?
This is due to micro-encapsulation of active principle: Tadalafil forms with water not a real physically homogeneous solution but a suspension of very small particles (not visible by eyes) not different from a colloidal suspension.

EMA says some other interesting things:
- pay attention to degradation: with water Tadalafil transform itself in different substances characterized by a lower molecular weight. This means that with water it will tend to be be less effective day by day. As a consequence we should conserve the water solution at low temperature and far from light (the home fridge is OK for some days).

- solubility is improved by adding sugar (particularly mannitol), lemon juice or carbonic acid (always present if you use bubbly drinks).

 

Edited by _Zoidberg_
Posted
17 hours ago, Wiley Coyote said:

Make life easy -buy a pill cuter !

really you can cut 8 small 2.5mg pieces from a 20mg pill?  ;-)

  • Haha 1
Posted
13 hours ago, _Zoidberg_ said:

really you can cut 8 small 2.5mg pieces from a 20mg pill?  😉

Portable Pill Cutter Box Tablet Splitter Divider Convenient Medicine Organizer

 

My pill cutter cuts clean to make two 10mg tablets from one 20 mg tablet.

Tricky for lesser doses, not very accurate

That is why I prefer to dissolve the tablet in Gatorade or similar. Makes it easy to take 5mg dose once a day.

Posted
On 26/06/2022 at 23:11, Farangkie said:

Sorry don't know, but personally I wouldn't import any pharmacuticles into Thailand from overseas. You run the risk of what you purchased being confiscated by Thai customs when it arrives in the country.

Unless you have a prescription for it...which is VERY easy to get online nowadays from various sellers in the West (Hims, Blue Chew, etc.), simply by filling out a questionnaire...your order will arrive in the mail with prescription info on the label.

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