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Androxal - a new drug to restore testosterone levels


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I was reading bloomberg news and came across an article about a new drug called Androxal.


Here is a quote:

"The drug maker said initial results showed patients taking the drug had total testosterone levels within a normal range at the end of 12 weeks. Its impact on sperm concentration also met FDA thresholds vs. patients taking a placebo. That’s significant because approved testosterone products can cause infertility in men".


The drug is not yet FDA approved though and is still in the study/test phase. The main acting agent in the drug is called enclomiphene. Here is what I googled about it:


"Enclomiphene (Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene constitutes the trans-stereoisomer of clomiphene citrate, a drug that has been widely prescribed for several decades for the treatment of female ovulatory dysfunction. Because of the antagonistic effects of enclomiphene, the drug has the potential to increase serum testosterone levels in men with secondary hypogonadism by restoring physiological endogenous testosterone secretion while maintaining testicular volume and, potentially, spermatogenesis. In clinical trials conducted to date, enclomiphene demonstrated significant efficacy in the physiological restoration of testosterone levels in males with secondary hypogonadism. The compound also exhibited an unanticipated favorable effect on fasting plasma glucose; this result has been accompanied by rapidly accumulating evidence from other researchers for a bidirectional relationship between low serum testosterone and obesity/metabolic syndrome (syndrome X) in men. Short-term clinical safety data for enclomiphene have been satisfactory and equivalent to safety data for testosterone gels and placebo. Enclomiphene demonstrates promise in the management of secondary hypogonadism associated with obesity, metabolic syndrome and, possibly, infertility, and should undergo placebo-controlled, randomized clinical trials for these indications."


So basically it's a modified version of the drug Clomid. I couldn't find any info on differences between the two. On some steroid forums people claim that it has lower estrogenic side effects but it might be just a wishful opinion of the posters.


Could be possible that the drug can be used in Post cycle therapy as an alternative to Clomid and Nolvadex.

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  • 2 weeks later...

Testosterone is just one of the hormones with influence on libido.

Also 98% of testosterone is being inactive by binding to SHBG and most of increase of testosterone above your normal levels gets converted into estrogen so not what you'd want from a miracle new drug.


If i'd be a developer of new sex drug I'd focus on freeing that 98% of your own active testosterone and blocking conversion to estrogen.


Similar if you'd just take antihypertensive that blocks just one mechanism of action instead of 3 as modern antihypertensive work on.

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